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KMID : 0191120100250121784
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Journal of Korean Medical Science
2010 Volume.25 No. 12 p.1784 ~ p.1791
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Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study
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Song Hyun-Joo
Kim Jin-Yong
Jung Sung-Ae
Kim Seong-Eun
Park Hye-Sook
Jeong Yool-Won
Hong Sung-Pil
Cheon Jae-Hee
Kim Won-Ho
Kim Hyo-Jong
Ye Byong-Duk
Yang Suk-Kyun
Kim Sang-Woo
Shin Sung-Jae
Kim Hyun-Soo
Sung Jae-Kyu
Kim Eun-Young
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Abstract
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Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic use. There is growing interest in probiotics for the treatment of AAD and Clostridium difficile infection because of the wide availability of probiotics. The aim of this multicenter, randomized, placebo-controlled, double-blind trial was to assess the efficacy of probiotic Lactobacillus (Lacidofil® cap) for the prevention of AAD in adults. From September 2008 to November 2009, a total of 214 patients with respiratory tract infection who had begun receiving antibiotics were randomized to receive Lactobacillus (Lacidofil® cap) or placebo for 14 days. Patients recorded bowel frequency and stool consistency daily for 14 days. The primary outcome was the proportion of patients who developed AAD within 14 days of enrollment. AAD developed in 4 (3.9%) of 103 patients in the Lactobacillus group and in 8 (7.2%) of 111 patients in the placebo group (P=0.44). However, the Lactobacillus group showed lower change in bowel frequency and consistency (50/103, 48.5%) than the placebo group (35/111, 31.5%) (P=0.01). Although the Lacidofil® cap does not reduce the rate of occurrence of AAD in adult patients with respiratory tract infection who have taken antibiotics, the Lactobacillus group maintains their bowel habits to a greater extent than the placebo group.
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KEYWORD
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Probiotics, Lactobacillus, Antibiotic-associated Diarrhea
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